GTTs and ITTs in mice: simple tests, complex answers

The two most common tests for determining metabolic health in mice are the glucose tolerance test (GTT) and insulin tolerance test (ITT). GTTs and ITTs are inexpensive and easy to perform, but how they are conducted and interpreted can radically change their meaning.

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Author information

Authors and Affiliations

1. University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC, Cambridge, UK Sam Virtue & Antonio Vidal-Puig
2. Wellcome Trust Sanger Institute, Hinxton, UK Antonio Vidal-Puig

1. Sam Virtue